Hydrochlorothiazide: The commonest signals and symptoms of overdose observed in human beings are All those a result of electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration resulting from extreme diuresis.
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Irbesartan is a particular competitive antagonist of AT1 receptors using a Substantially larger affinity (in excess of 8500-fold) for the AT1 receptor than for your AT2 receptor, and no agonist action.
Blockade on the AT1 receptor removes the negative opinions of angiotensin II on renin secretion, nevertheless the ensuing greater plasma renin action and circulating angiotensin II tend not to prevail over the results of irbesartan on hypertension.
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